Peptide Database

Peptide NameDefensin-A (AaDef)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length98 amino acids

Chemical FormulaC459H729N129O140S9

DescriptionStandard

        MKSITVICFLALCTVAITSAYPQEPVLADEARPFANSLFDELPEETYQAAVENFRLKRATCDLLSGFGVGDSACAAHCIARGNRGGYCNSKKVCVCRN
    

Molecular Weight10583.06 Da

Isoelectric Point (pI)6.53

Net Charge (pH 7.0)-0.48

Net Charge (pH 7.4) -0.88

Charge Density (pH 7.0) -0.0049

GRAVY Index0.11

Hydrophobic Moment 0.61

Boman Index0.06

Instability Index38.76

Aliphatic Index 81.73

Aromaticity 0.0816

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4970.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4312.87

LogP -47.19

H-bond Donors 157.0

H-bond Acceptors 150.0

Rotatable Bonds 344.0

Heavy Atoms 737.0

Ring Count 13.0

Amide Bonds 104.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0211082 VERIFIED: YES

Provenance & Taxonomy

OrganismAedes aegypti [Animal]

FamilyDefensin

Tax ID7159

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Anti-Gram-negative Non-hemolytic

TargetE. cloacae (Gram-negative)