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MYP_014179
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Basic Information
Vhl-2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C133H200N36O44S6
Standard
Sequence
GLPVCGETCFTGTCYTNGCTCDPWPVCTRN
Physicochemical Analysis
3199.62 Da
4.37
-1.30
-1.59
-0.0432
-0.04
0.32
0.12
39.21
32.33
0.1000
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1260.93
-17.01
49.0
49.0
91.0
219.0
7.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0354620 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Cyclotide
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
Bio-Activity Profile
Anticancer Antiviral Anti-HIV Cytotoxic
HIV
PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0371337 VERIFIED: YES
Provenance & Taxonomy
Viola hederaceae [Plant]
Cyclotide
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
PaperIsolation and characterization of novel cyclotides from Viola hederaceae: solution structure and anti-HIV activity of vhl-1, a leaf-specific expressed cyclotide.
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