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MYP_014179
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Basic Information
Vhl-2
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
30 amino acids
C133H200N36O44S6
Standard
Sequence
GLPVCGETCFTGTCYTNGCTCDPWPVCTRN
Physicochemical Analysis
3199.62 Da
4.37
-1.30
-1.59
-0.0432
-0.04
0.32
0.12
39.21
32.33
0.1000
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1260.93
-17.01
49.0
49.0
91.0
219.0
7.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0089076 VERIFIED: YES
Provenance & Taxonomy
Australia violet [Plant]; Insecta [Animal]
33090; 50557
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0112240 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Defensin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antiviral
HIV
0.87 μM
EC50
PaperPubMed PMID: 15824119 PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
RECORD: Rec_0152820 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0185539 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
cyclotide family
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
5-19; 9-21; 14-27
Bio-Activity Profile
Antimicrobial cyclotide family Host defense
PaperPDB 2KUK structural record; NMR; chain A; residues 5-30
RECORD: Rec_0233782 VERIFIED: YES
Provenance & Taxonomy
Viola hederacea [Plant]
Defensin
Structure & Mods
head-to-tail cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antiviral Hemolytic
PaperPubMed PMID: 15824119 PMID15824119 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15824119/
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