Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length645 amino acids

Chemical FormulaC3155H4989N861O893S26

DescriptionStandard

        MHTHRDTHTLQAPQLPGSPSGCLWGCGPNHGRQQSSPSSTPTQFPSSFLHPTGLRFLSQLLYRSLAPLQGLQALAASEDEDMARAPGSALRRAALLVLATLGTAVIATTNPGIVARITQKGLDYACQQGVAVLQKELEKIKIPDFSGTFKIKHLGKGKYSFYSMVIRGFQLPSSQIKLAPSKGLDLSMRNANVKISGKWKARKKFIKTSGNFDLSVEGVSISAGLQLGFDPASGLPTATCSSCNNDINSVHVHISGGKLGWLIQLFHKKIESSIRKTMSSKICQVVTSSVSSKLQSYLKTLRVTTKIDQVAGINYSLVAPLTATADSLDGQLKGEFYNVAHPSPPPFAPRALAFPPDHDRMVYLGISEYFFNTAGFVYQQAGVLHLTVTDDMIPKGSKFRLTTTFFGALIPQVAKMFPNMTVQLNIWASCPPHLTMLPAGLVFTPDLETQAFAVLPNSSLAPLFVLHLSTNVSMEVGATSDRLVGKLRLDRLLLELKHSDVGPFSVEVLQAIMNYVLPTVAIPKINERLQKGFLLPLPANVQLFNLVLQSHQWPGRGQWPCRRNCSESRCLTSPGTSRSSPLAEGTMSSTGNYTAPLMCRSRALPFRSTFSWAGSPLGGPLLLPPAAAATFETWRWTYREIWGGC
    

Molecular Weight70103.29 Da

Isoelectric Point (pI)9.66

Net Charge (pH 7.0)25.80

Net Charge (pH 7.4) 24.49

Charge Density (pH 7.0) 0.0400

GRAVY Index-0.03

Hydrophobic Moment 0.70

Boman Index0.10

Instability Index46.90

Aliphatic Index 88.64

Aromaticity 0.0822

Extinction Coeff. Reduced 74370.00

Extinction Coeff. Oxidized 75120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0240801 VERIFIED: NO

Provenance & Taxonomy

OrganismAiluropoda melanoleuca [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria