Peptide Database

Peptide NameOsteocrin

Function Ontology

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length50 amino acids

Chemical FormulaC241H397N85O69S

DescriptionStandard

        SFSGFGSPLDRLSAGSVDHKGKQRKVVDHPKRRFGIPMDRIGRNRLSNSR
    

Molecular Weight5621.32 Da

Isoelectric Point (pI)11.79

Net Charge (pH 7.0)7.63

Net Charge (pH 7.4) 7.32

Charge Density (pH 7.0) 0.1527

GRAVY Index-1.00

Hydrophobic Moment 0.73

Boman Index-0.34

Instability Index33.87

Aliphatic Index 58.40

Aromaticity 0.0600

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2539.57

LogP -32.42

H-bond Donors 92.0

H-bond Acceptors 80.0

Rotatable Bonds 192.0

Heavy Atoms 396.0

Ring Count 8.0

Amide Bonds 52.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0100865 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyOsteocrin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Targetnatriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (By similarity)

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0253869 VERIFIED: YES