Peptide Database

Peptide NameUnnamed

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Immunology ▸ Inflammation modulation ▸ Anti-inflammatory

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length6 amino acids

Chemical FormulaC38H64N12O8

DescriptionStandard

        RRPYIL
    

Molecular Weight816.99 Da

Isoelectric Point (pI)10.84

Net Charge (pH 7.0)1.76

Net Charge (pH 7.4) 1.55

Charge Density (pH 7.0) 0.2932

GRAVY Index-0.60

Hydrophobic Moment 0.36

Boman Index-0.37

Instability Index168.00

Aliphatic Index 130.00

Aromaticity 0.1667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 344.06

LogP -1.10

H-bond Donors 13.0

H-bond Acceptors 10.0

Rotatable Bonds 24.0

Heavy Atoms 58.0

Ring Count 2.0

Amide Bonds 5.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0153437 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Anti-inflammatory

RECORD: Rec_0170569 VERIFIED: YES

Provenance & Taxonomy

OrganismUnknown [Animal]

FamilyNeurotensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide Hormone Neurotensin receptor agonist Receptor binding

Targetrat neurotensin receptor 1 (NTS1-H4)

Activity3.2±2.4×10^-11 M

MethodSPR binding (Kd)

Half-LifeMammalian: 1 hour; Yeast: 2 min; E. coli: 2 min

RECORD: Rec_0199150 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

FamilyNeurotensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide Hormone

RECORD: Rec_0318974 VERIFIED: NO

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0432058 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyNeurotensin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide Neurotensin receptor ligand Receptor binding

Targethuman frontal cortex neurotensin binding sites

Activity0.52 nM

Methodradioligand saturation binding (Kd)