Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length466 amino acids

Chemical FormulaC2310H3608N594O669S22

DescriptionStandard

        MFLSVTAVLMLFSCAHGENPAIQVILTNKGLQYGKHAGTDWIQKMLEHVTLPDISGKVNVGFWCSIHYTLTNTSIEKCDLPEPSADFYPDATGLKTSMSGLSVALSGQWMTHFGIIHDKGSFDMAILGVDVTSVVELGKDADGHLSVSSANCVAQVGDVDVRFHGGASWIFKRFVKHFKKRISKEIENRICPNVEELIASVEYHLQAMNVSFEVDPAMAMNLSLSTSPTIDVSSLNLGLKGEFFSEKTRADPPFEAQPFTMPEQQAFMLSVGLSEFTLNSASYVYYSYGVFQRFIDDSMIPPGFPLHLNTSLMGPYVPQLPKMFPGLLMDLHVYARDTPMFSFQPGAVKLGIQGAVKAFAIQPNGTQTPLFQLNIDLTLSSKVWIADGKVKGSVSTDNFTLTLAGSEVGSFGTDALENIARKVVEMGLEILNKRLGRGLVLPRLKRAQLVNSVLKVQEVSIGYYKK
    

Molecular Weight51110.36 Da

Isoelectric Point (pI)6.19

Net Charge (pH 7.0)-4.46

Net Charge (pH 7.4) -5.46

Charge Density (pH 7.0) -0.0096

GRAVY Index0.07

Hydrophobic Moment 0.91

Boman Index0.15

Instability Index29.92

Aliphatic Index 91.59

Aromaticity 0.0944

Extinction Coeff. Reduced 45380.00

Extinction Coeff. Oxidized 45630.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0370762 VERIFIED: NO

Provenance & Taxonomy

OrganismScophthalmus maximus [Bacterium]

FamilyBPI

Tax ID52904

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence