Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length493 amino acids

Chemical FormulaC2488H3883N629O729S23

DescriptionStandard

        MPECDWWLKTQSESVTTQRRHHTDVRRVCPGTELGREGEWLPAAEFKAQVENTSTSKSEGIEGAPQLWTLPLLEVSVTCGSLPCAKAAMITHPDCKLPELETRPMNMRKKTVQVVWGCFFLWNLYISSSQTIYPGIKARATQRALDYGVQAGMQMIEQMVKEKDIPDVKGTESLEFLKVDYVNYNFSNIKINAFSFPNTSLAFVPGVGIKALTNHGTANISANWEIKSPLFQDTGGADLYLSGVYFTGIVILARNDFGRPTLKLQDCYAQVSHAHVSFSGELKVLYNSLAEPMEKPILKNLNKILCPIITSEVEALNANLSVLEVFTKIDNYTLLDYSLINSPEITENYMDLNLKGVFYPLENLTDPPFSPVPFVLPERSDSMLYIGISKYFFKSASFAYFTAGAFNVTLSTKEISSHLVQNSQGLGNMLSRFAEIYILSQPFMVRIMATEPPVVSLLPGNFTLDIPASIMILTQSKNSTAETIVSMDFIILR
    

Molecular Weight55007.72 Da

Isoelectric Point (pI)5.54

Net Charge (pH 7.0)-7.90

Net Charge (pH 7.4) -8.72

Charge Density (pH 7.0) -0.0160

GRAVY Index-0.01

Hydrophobic Moment 0.74

Boman Index0.12

Instability Index39.19

Aliphatic Index 92.15

Aromaticity 0.0994

Extinction Coeff. Reduced 63830.00

Extinction Coeff. Oxidized 64330.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0098967 VERIFIED: NO

Provenance & Taxonomy

OrganismDiceros bicornis minor [Plant]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria