Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length471 amino acids

Chemical FormulaC2314H3740N586O652S17

DescriptionStandard

        MSAWLTLLALIPLTLAINPGVKVKLTEKGLEYGREIGMASLQKKLKTIKVPDLSGSAKVAPIGKVTYSLTGMQIVNLGLPKSVLGLVPGTGVNLSIGNAFLNLHGNWRVRYLKFIKDSGSFDLGIKGLTITTSIAIKSDETGRPSVSSINCVTSLGSATIKFHGGASWLYNLFSSYIDKALRNSLQKKICPLVADAVTDMNPHLKTLNVLAKVDKYAEIEYSMVESPAISKSCIDLGLKGEFYNVGAHQEPPFSATPFSLPPQISNMLYIGISSFTTNSAGFVYNKAGALSLYVTDGMIPPSSPIRLNTRTFGAFIPQIAKRFPGLMMKLLVKTVQEPIITFEPNNVTLQATGTVTAYAIQPNTTLSPLFVLNMEASVSARVYVTGVKLAGAMTLNKIQMTLGKSYVGDFQVKSLDNIFLMVLKVAVIPKVNARLEKGYPLPSLGKMNLVNTQLQVLKGYILIGTDVLFTG
    

Molecular Weight50747.09 Da

Isoelectric Point (pI)9.67

Net Charge (pH 7.0)19.82

Net Charge (pH 7.4) 19.25

Charge Density (pH 7.0) 0.0421

GRAVY Index0.25

Hydrophobic Moment 0.70

Boman Index0.19

Instability Index24.02

Aliphatic Index 107.20

Aromaticity 0.0786

Extinction Coeff. Reduced 40340.00

Extinction Coeff. Oxidized 40465.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0077430 VERIFIED: NO

Provenance & Taxonomy

OrganismPlecoglossus altivelis altivelis [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence