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MYP_013909
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Basic Information
Substance P-like peptide 2
Antimicrobial
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Neurological / Signaling ▸ Tachykinin peptide
Regulatory peptide ▸ Biological modulation
Standard
11 amino acids
C59H84N14O17S
Standard
Sequence
QPNPNEFFGLM
Physicochemical Analysis
1293.45 Da
4.05
-1.24
-1.44
-0.1125
-0.57
0.21
0.15
23.98
35.45
0.1818
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
503.31
-3.94
14.0
17.0
38.0
91.0
4.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0044019 VERIFIED: YES
Provenance & Taxonomy
Pseudophryne guentheri [Animal]
Substance P-like peptide
30349
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
Pyroglutamate
Amidation
Bio-Activity Profile
Neuropeptide Neuromodulator Vasoactive Vasodilator Receptor modulation
Mammalian: 0.8 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Substance P-like peptide 2 (Pseudophryne guentheri): PMID 2356157 PMID2356157 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2356157/
RECORD: Rec_0087734 VERIFIED: YES
Provenance & Taxonomy
Pseudophryne guentheri [Animal]
Substance
Structure & Mods
ribosomal mature linear peptide [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
Bio-Activity Profile
Smooth muscle contraction Vasorelaxant
PaperM. Simmaco et al. / Peptides 11 (1990) 299-304. Six novel tachykinin- and bombesin-related peptides from the skin of the Australian frog Pseudophryne guntheri Evidence URLhttps://www.uniprot.org/uniprotkb/P42990/entry
RECORD: Rec_0110832 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0275759 VERIFIED: YES
Provenance & Taxonomy
Pseudophryne guentheri [Animal]
Tachykinin
30349
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Pyroglutamate
Amidation
Bio-Activity Profile
Tachykinin Neuropeptide Neuromodulator
PMID2356157 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2356157/
RECORD: Rec_0398544 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neuropeptide
Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/