Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length456 amino acids

Chemical FormulaC2272H3528N616O635S12

DescriptionStandard

        TDPGFVVRITQAGLDYAHQHGIAVLEKELAQLKLPDISGDFRIRHMARVHYELSRLDLRSFHLPYSRISLVPNVGLQVSISNAFADMDGNWRVKMHFIRDHGSFDLKVENVYIKISLKLGSDASGKPTIDTSDCSTRISKVRVHFSGKFGWLYNLFYNAVESRFRKTLESKVCESVASSVRSELQPYLHTLPVTARIDAMAGIDYALVAPPTATAQSLDVDLKGEFFSLAHRSTVPFPPLPLPLPPDHDRMVYFGASSYFFNTAGFAYHAAGVLAFDITASVIPKGIDFHLNTTTFSAFIPQLDRMYPDTPMKLRLSAASAPFLSISPGGLSLQPVVDVQAYAILPNASLAPLFLLSLVSNVSAVINVKSGHIVGSLAVGRYRGSHTGGCLGGWGEEVAALCSHSHCPNAHVLSLAARLEQGFPLPLPDRIQLSNILVRFHQNFLLLGADVHYQPR
    

Molecular Weight50016.84 Da

Isoelectric Point (pI)8.49

Net Charge (pH 7.0)4.12

Net Charge (pH 7.4) 2.77

Charge Density (pH 7.0) 0.0090

GRAVY Index0.10

Hydrophobic Moment 0.69

Boman Index0.13

Instability Index34.40

Aliphatic Index 97.74

Aromaticity 0.0965

Extinction Coeff. Reduced 38850.00

Extinction Coeff. Oxidized 39100.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0335435 VERIFIED: NO

Provenance & Taxonomy

OrganismAegotheles bennettii [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria