Peptide Database

Peptide NameBactericidal permeability-increasing protein

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length490 amino acids

Chemical FormulaC2496H3918N620O722S16

DescriptionStandard

        MESEKILIVWGCLLLWNPLIQSTQLYPGIKVRITQKGLDYGIQAGMEAIELIVKKNGIPDFKGSETLEFLKVDYVDYNFSNIKISSFSFPNISLTPLSGVGVKVLSNHGSTNISMRWEISSPLFKDEGGAALFLGEIFFLGLVNLSRSDTGHPSMKLQDCYVRIGLARISFTGELSVLYNSFAEPMEKPILKTLNKKLCPIITDQLESINANISSLDVVTMFGEDILLDYSLLDSPEITQSSIDLNLKGTFYPVGNLTDPPFQPVPFTLPDRSDSMLYIGISEYFLKSASFTYFITGAFNVTLTTKELSKHLIQNPQGIGSLFSQIAELYIMAQPLMMRILTTEPPVVNLEPNNFTLNIPGSVVMLTKPENTTEEAIVSMDFVASTSVGLAILGRKLICSLSLNRFRLSGPESNHSSIEVLRFENIFSSILHFGVFPLVNARLQQGFPLPNPHQISLVNSDIEVHKGFLLVSTDLRYEPLWKKQRHLDEW
    

Molecular Weight54676.57 Da

Isoelectric Point (pI)5.32

Net Charge (pH 7.0)-10.78

Net Charge (pH 7.4) -11.57

Charge Density (pH 7.0) -0.0220

GRAVY Index0.11

Hydrophobic Moment 0.61

Boman Index0.16

Instability Index40.33

Aliphatic Index 105.39

Aromaticity 0.0959

Extinction Coeff. Reduced 46870.00

Extinction Coeff. Oxidized 47120.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0420900 VERIFIED: NO

Provenance & Taxonomy

OrganismSarcophilus harrisii [Animal]

FamilyBPI/LBP

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic Non-ribosomal

TargetGram-negative bacteria

MethodQualitative functional evidence