Peptide Database

Peptide Namesynthetic peptide from alpha-gliadin

Function Ontology

Venom / Toxin ▸ General toxin ▸ Celiac toxic

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC67H97N19O19

DescriptionStandard

        PYSQPQPFRPQQ
    

Molecular Weight1472.60 Da

Isoelectric Point (pI)9.18

Net Charge (pH 7.0)0.96

Net Charge (pH 7.4) 0.90

Charge Density (pH 7.0) 0.0798

GRAVY Index-2.02

Hydrophobic Moment 0.17

Boman Index-0.35

Instability Index137.57

Aliphatic Index 0.00

Aromaticity 0.1667

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 617.78

LogP -6.82

H-bond Donors 19.0

H-bond Acceptors 20.0

Rotatable Bonds 41.0

Heavy Atoms 105.0

Ring Count 6.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0136328 VERIFIED: YES

Provenance & Taxonomy

OrganismTriticum aestivum [Plant]

FamilyGliadin-derived

Tax ID4565;0

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Celiac toxic

Targetgliadin-reactive enterocyte / calreticulin cross-reactivity assays

PaperKrupickova S., Tuckova L., Flegelove Z., Michalak M., Walters J. R. F., Whelan A., Harries J., Vencovsky J., Tlaskalova-Hogenova H.. Identification of common epitopes on gliadin, enterocytes, and calreticulin recognised antigliadin antibodies of patients with coeliac disease. Gut, 1999, 44, 168-173. PMID9895374 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/9895374/

RECORD: Rec_0396725 VERIFIED: YES