Peptide Database

Peptide NameSLAY-screened peptide P1080

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC86H145N25O31S

DescriptionStandard

        SFSGLCEDTETILKRRTT
    

Molecular Weight2057.29 Da

Isoelectric Point (pI)5.90

Net Charge (pH 7.0)-0.54

Net Charge (pH 7.4) -0.77

Charge Density (pH 7.0) -0.0302

GRAVY Index-0.60

Hydrophobic Moment 0.53

Boman Index-0.22

Instability Index78.41

Aliphatic Index 65.00

Aromaticity 0.0556

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 941.12

LogP -12.05

H-bond Donors 36.0

H-bond Acceptors 32.0

Rotatable Bonds 70.0

Heavy Atoms 143.0

Ring Count 1.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0042789 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/