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MYP_013732
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Basic Information
Ranatuerin-1C
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antimicrobial ▸ Antifungal ▸ Anti-Candida
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
25 amino acids
C114H206N32O31S3
Standard
Sequence
SMLSVLKNLGKVGLGLVACKINKQC
Physicochemical Analysis
2617.25 Da
9.70
3.44
3.19
0.1375
0.64
0.57
0.18
26.11
132.40
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1035.53
-9.68
37.0
38.0
94.0
180.0
0.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0335004 VERIFIED: YES
Provenance & Taxonomy
Lithobates clamitans [Animal]
Frog skin active peptide (FSAP); Ranatuerin subfamily
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Candida Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Escherichia coli
PMID10822101 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10822101/
RECORD: Rec_0364904 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0393975 VERIFIED: YES
Provenance & Taxonomy
American green [Animal]
Ranatuerin
33208
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
19-25
Bio-Activity Profile
Antimicrobial
PMID10651828 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10651828/
RECORD: Rec_0396602 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0418122 VERIFIED: YES
Provenance & Taxonomy
Rana clamitans [Animal]
Ranatuerin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Cyclization
19-25
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
58 μM
MIC
PMID10822101 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10822101/
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