Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length279 amino acids

Chemical FormulaC1431H2214N356O392S11

DescriptionStandard

        MEKPWDSDPAFQLPPAHVMTKIDAVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAILPNSSLASLFLIGMHTTGSMEVSAESDRLVGELKLDRLLLELKHSNIGPFPVALLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK
    

Molecular Weight31029.75 Da

Isoelectric Point (pI)6.13

Net Charge (pH 7.0)-3.69

Net Charge (pH 7.4) -4.43

Charge Density (pH 7.0) -0.0132

GRAVY Index0.05

Hydrophobic Moment 0.66

Boman Index0.16

Instability Index40.50

Aliphatic Index 94.34

Aromaticity 0.1004

Extinction Coeff. Reduced 18910.00

Extinction Coeff. Oxidized 18910.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0400405 VERIFIED: NO

Provenance & Taxonomy

OrganismPan paniscus [Animal]

FamilyBPI

Tax ID9597

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence