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MYP_013638
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Basic Information
C41 [Q29X](Q29C)
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
not Standard
41 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
EWDREINNYTSLIHSLIEESQNQQEKNEXELLELDKWASLW
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0332367 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 29 indicates PEG2000-Cys.
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 | CHO-WT cells; K652 cells
0.0055±0.0005 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperSite-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation. | Danial M, van Dulmen TH, Aleksandrowicz J, Pötgens AJ, Klok HA. | Bioconjug Chem. 2012 Aug 15;23(8):1648-60. | DOI:10.1021/bc3002248 | PMID:22770564 PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
RECORD: Rec_0408391 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
None
The 'X' at position 29 indicates PEG750-Cys.
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 | CHO-WT cells; K652 cells
0.0052±0.0008 μM
IC50
Mammalian: 1 h; Yeast: 30 min; E. coli: >10 h
PaperSite-specific PEGylation of HR2 peptides: effects of PEG conjugation position and chain length on HIV-1 membrane fusion inhibition and proteolytic degradation. | Danial M, van Dulmen TH, Aleksandrowicz J, Pötgens AJ, Klok HA. | Bioconjug Chem. 2012 Aug 15;23(8):1648-60. | DOI:10.1021/bc3002248 | PMID:22770564 PMID22770564 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22770564/
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