Peptide Database

Peptide NameSLAY-screened peptide P133

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H153N37O22S

DescriptionStandard

        RLHFGRGARVHVHYGMGAVH
    

Molecular Weight2257.58 Da

Isoelectric Point (pI)11.71

Net Charge (pH 7.0)3.11

Net Charge (pH 7.4) 2.70

Charge Density (pH 7.0) 0.1554

GRAVY Index-0.23

Hydrophobic Moment 0.54

Boman Index0.02

Instability Index9.30

Aliphatic Index 73.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 936.87

LogP -8.21

H-bond Donors 35.0

H-bond Acceptors 30.0

Rotatable Bonds 71.0

Heavy Atoms 160.0

Ring Count 6.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0004983 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/