Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2315H3720N588O669S20

DescriptionStandard

        MFLCCWLALVALIPMTLGTNPGVEVKLTEKGLEYGRQLGMTSILQKLKTIKVPDISGSQEVPPIGNVEYSLSNMQIVDVGLPKSGLDLVPGTGVRLSIGNAFIHLQGNWRVKYIKIIKDSGSFDLNVNDLAITTSIAIKSDETGRPVVSSVSCAATVGSASIRFHGGASWLYNLFTDFIDKALRNALQKQICPLVADAVSDLNPHLKTLNVVAKVDQYAEIEYSMVSSPTVSNSSIDLSLKGEFYNIGKHQEPPFSPAAFSLPPQINNMLYIGVSVFTTNSAAFVYNTAGALSLYITDDMIPQGSPIRLNTRTFGAFIPQIAARFPGLMMKLLVKTVKCPVITFEPNNVTIQATGTVTAYAIQANATLSPLFVLNLETSVSVQLFVSEMRLAGAVNLNKMDVTLGTSYVGEFQVKSLDSILQMVIKVVVIPKVNVQLAKGYPLPTLGKMKLVNTQLQVLKGYMLIGTDVQFMG
    

Molecular Weight51135.14 Da

Isoelectric Point (pI)8.76

Net Charge (pH 7.0)4.82

Net Charge (pH 7.4) 4.23

Charge Density (pH 7.0) 0.0102

GRAVY Index0.29

Hydrophobic Moment 0.79

Boman Index0.20

Instability Index28.27

Aliphatic Index 107.93

Aromaticity 0.0761

Extinction Coeff. Reduced 37360.00

Extinction Coeff. Oxidized 37610.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0107818 VERIFIED: NO

Provenance & Taxonomy

OrganismPerca flavescens [Bacterium]

FamilyBPI

Tax ID8167

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence