Peptide Database

Peptide NameSLAY-screened peptide P1023

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length12 amino acids

Chemical FormulaC57H90N14O20S

DescriptionStandard

        TVQINSADPYCI
    

Molecular Weight1323.47 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.61

Net Charge (pH 7.4) -1.82

Charge Density (pH 7.0) -0.1343

GRAVY Index0.22

Hydrophobic Moment 0.09

Boman Index0.20

Instability Index2.09

Aliphatic Index 97.50

Aromaticity 0.0833

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 558.80

LogP -6.13

H-bond Donors 19.0

H-bond Acceptors 20.0

Rotatable Bonds 39.0

Heavy Atoms 92.0

Ring Count 2.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0129772 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/