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MYP_013406
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Basic Information
RJ5-I15E16
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Herpesvirus ▸ Anti-HSV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
21 amino acids
C101H192N32O24
Standard
Sequence
AKKAAKKAKKAAKKIEKAAKK
Physicochemical Analysis
2238.81 Da
10.65
9.79
9.58
0.4661
-1.31
0.77
-0.52
26.40
56.67
0.0000
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
968.84
-8.42
34.0
34.0
90.0
157.0
0.0
20.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0006044 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 16923027 PMID16923027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16923027/
RECORD: Rec_0018532 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
Herpes simplex virus 1(HSV-1):inhibition of viral entry into Vero cells
112 μM
IC50
PaperPubMed PMID: 16923027 PMID16923027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16923027/
RECORD: Rec_0023357 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
toxicity against Human fibroblasts MRC-5 cells up to 448 μM
448 μM
Cytotoxicity
PaperPubMed PMID: 16923027 PMID16923027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16923027/
RECORD: Rec_0205416 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HSV Entry inhibition
Herpes simplex virus 1(HSV-1) | Vero cells
112 μM
IC50
Mammalian: 4.4 h; Yeast: >20 h; E. coli: >10 h
PaperPrediction of activity, synthesis and biological testing of anti-HSV active peptides. | Jenssen H, Gutteberg TJ, Rekdal Ø, Lejon T. | Chem Biol Drug Des. 2006 Jul;68(1):58-66. | DOI:10.1111/j.1747-0285.2006.00412.x | PMID:16923027 PMID16923027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16923027/
RECORD: Rec_0356151 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
PaperPubMed PMID: 16923027 PMID16923027 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/16923027/