Peptide Database

Peptide NameSLAY-screened peptide P5840

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC119H163N27O28S4

DescriptionStandard

        HFWYTLPMFNRCIYCSSCYL
    

Molecular Weight2547.99 Da

Isoelectric Point (pI)7.95

Net Charge (pH 7.0)0.81

Net Charge (pH 7.4) 0.51

Charge Density (pH 7.0) 0.0407

GRAVY Index0.36

Hydrophobic Moment 0.45

Boman Index0.25

Instability Index31.86

Aliphatic Index 58.50

Aromaticity 0.3000

Extinction Coeff. Reduced 9970.00

Extinction Coeff. Oxidized 10095.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 878.27

LogP -3.68

H-bond Donors 35.0

H-bond Acceptors 34.0

Rotatable Bonds 73.0

Heavy Atoms 178.0

Ring Count 9.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0098318 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/