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MYP_013332
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Basic Information
EC-hepcidin1
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
88 amino acids
C429H682N112O129S6
Standard
Sequence
MKTFSVAVAVAIVLAFICTQESSALPVTGVEELVELVSSDDPVADHQELPVELGERLFNIRKKRASPKCTPYCYPTRDGVFCGVRCDF
Physicochemical Analysis
9665.07 Da
4.99
-3.44
-3.81
-0.0391
0.18
0.54
0.09
55.14
91.82
0.0795
2980.00
3230.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
3824.40
-35.39
136.0
133.0
311.0
676.0
14.0
90.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0012490 VERIFIED: YES
Provenance & Taxonomy
Epinephelus coioides [Animal]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
Gram+ Staphylococcus aureus
100 μg/mL
MIC
PaperMolecular cloning and characterization of two novel hepcidins from orange-spotted grouper, Epinephelus coioides
RECORD: Rec_0081442 VERIFIED: YES
Provenance & Taxonomy
Epinephelus coioides [Animal]
Structure & Mods
cyclic/stapled peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antiviral
Singapore grouper iridovirus (SGIV):strongly inhibit the replication of SGIV
PaperPubMed PMID: 21145974 PMID21145974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21145974/
RECORD: Rec_0091543 VERIFIED: YES
Provenance & Taxonomy
Epinephelus coioides [Animal]
94232
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
There are two pairs of disulfide bonds.
Bio-Activity Profile
Antiviral Anti-SGIV Entry inhibition
Singapore grouper iridovirus (SGIV)
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperMolecular cloning and characterization of two novel hepcidins from orange-spotted grouper, Epinephelus coioides. | Zhou JG, Wei JG, Xu D, Cui HC, Yan Y, Ou-Yang ZL, Huang XH, Huang YH, Qin QW. | Fish Shellfish Immunol. 2011 Feb;30(2):559-68. | DOI:10.1016/j.fsi.2010.11.021 | PMID:21145974 PMID21145974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21145974/
RECORD: Rec_0179598 VERIFIED: YES
Provenance & Taxonomy
Epinephelus coioides [Animal]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Staphylococcus aureus
PMID21145974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21145974/
RECORD: Rec_0222746 VERIFIED: YES
Provenance & Taxonomy
Epinephelus coioides [Animal]
Hepcidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Vibrio vulnificus
PMID21145974 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21145974/
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