Peptide Database

Peptide NameLanadelumab

Function Ontology

Immunology ▸ Immune modulation ▸ Immunomodulatory activity

Immunology ▸ Immunomodulation ▸ Immuno-oncology

Therapeutic / Biomedical activity ▸ Enzyme replacement therapy

Standard StatusStandard

Sequence Length451 amino acids

Chemical FormulaC2200H3422N590O671S18

DescriptionStandard

        EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYIMMWVRQAPGKGLEWVSGIYSSGGITVYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAYRRIGVPRRDEFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPG
    

Molecular Weight49449.43 Da

Isoelectric Point (pI)8.51

Net Charge (pH 7.0)5.63

Net Charge (pH 7.4) 4.68

Charge Density (pH 7.0) 0.0125

GRAVY Index-0.35

Hydrophobic Moment 0.52

Boman Index0.02

Instability Index47.51

Aliphatic Index 72.28

Aromaticity 0.0909

Extinction Coeff. Reduced 72310.00

Extinction Coeff. Oxidized 72935.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0007040 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; Cricetulus griseus [Animal]

FamilyMonoclonal antibody

Tax ID9606;10029

Structure & Mods

Configlinear peptide/protein therapeutic [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Immunomodulatory Enzyme replacement Immuno-oncology

Half-LifeLanadelumab has a prolonged half-life which is typical of a human monoclonal antibody and it ranged from 13.8 to 15 days.[A38677]