Peptide Database

Peptide NameSLAY-screened peptide P5744

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC104H157N27O30S2

DescriptionStandard

        CSTDFTLWHPLTIHQTNLAM
    

Molecular Weight2329.65 Da

Isoelectric Point (pI)5.97

Net Charge (pH 7.0)-1.07

Net Charge (pH 7.4) -1.39

Charge Density (pH 7.0) -0.0537

GRAVY Index0.10

Hydrophobic Moment 0.15

Boman Index0.23

Instability Index26.62

Aliphatic Index 83.00

Aromaticity 0.1000

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 905.21

LogP -7.97

H-bond Donors 32.0

H-bond Acceptors 33.0

Rotatable Bonds 70.0

Heavy Atoms 163.0

Ring Count 6.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0420608 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/