Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length444 amino acids

Chemical FormulaC2155H3404N576O622S16

DescriptionStandard

        MAREPDKALTRATLVVLATLGTAVIATTNPGVVARITQKGLDYACQQGVAVLQKELEKITIPTFSGSFKIKHLGKGHYSFHSMAIRGFQLPSSQIKLAPSEGLDLSITNANVKMSGKWKARKNFIKTSGNFDLSVEGVSISAVLKLGFDPASGHCTVSCSRCNNHINSVRVHISGSSLGWLINLFHEKMESSLRNRMTSEICKVVTSSVSSKLQRYLETLPVTTRIDRVAGIDYSLVAPPTATTDSLDGQLKGEFFRWAHPSPPPFAPPPLAFPSDHDRMVYLGISNYFFNTAGFVYQQAGVLNLTVTDNVIPKESKFRLTTDVFGILIPQVAKMFPNMKVQLVFWASSPPHLTVHPEGLVLTPTLDAQAFAVLPNSSLAPLFVLRLVSGSQVWADEGSALGVGGPGCTCPGSDAPGSETRATVLTVSGFCGHSYIELFILSLP
    

Molecular Weight47846.61 Da

Isoelectric Point (pI)9.03

Net Charge (pH 7.0)8.50

Net Charge (pH 7.4) 7.48

Charge Density (pH 7.0) 0.0191

GRAVY Index0.10

Hydrophobic Moment 0.71

Boman Index0.14

Instability Index39.15

Aliphatic Index 91.98

Aromaticity 0.0811

Extinction Coeff. Reduced 39420.00

Extinction Coeff. Oxidized 39920.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0075482 VERIFIED: NO

Provenance & Taxonomy

OrganismLynx pardinus [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence