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MYP_013127
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Basic Information
Unnamed
Cardiovascular ▸ Blood pressure regulation ▸ Antihypertensive
Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory
Hemostasis ▸ Antithrombotic activity
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Sensory / Food function ▸ Taste-active peptide
Sensory / Food function ▸ Taste-active peptide ▸ Bitter peptide
Therapeutic / Biomedical activity ▸ Regenerative medicine ▸ Bone metabolism ▸ Osteoanabolic activity
Standard
7 amino acids
C38H59N7O8
Standard
Sequence
GPFPIIV
Physicochemical Analysis
741.92 Da
5.53
-0.24
-0.44
-0.0343
1.77
0.17
0.82
51.47
152.86
0.1429
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
220.34
0.94
6.0
8.0
18.0
53.0
3.0
6.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0277921 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive
Spontaneously hypertensive rats (SHR)
4 μM
IC50
PaperAntihypertensive effect of the peptides derived from casein by an extracellular proteinase from Lactobacillus helveticus CP790 PMID8201050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8201050/
RECORD: Rec_0278891 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antihypertensive ACE inhibitory
Angiotensin-converting enzyme (ACE)
PaperVariability of hydrolysis of β-, αs1-, and αs2-caseins by 10 strains of Streptococcus thermophilus and resulting bioactive peptides; PMID 17483275 PMID22103626;17483275 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22103626/
RECORD: Rec_0295519 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory ACE inhibitory
ACE
4.0 μM
IC50
RECORD: Rec_0308432 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Osteoanabolic
Epidermal growth factor receptor
PaperPreparation, identification and screening of anti-osteoporosis milk-derived peptides: intervention effects in osteoporosis rats. Food Bioscience 62:105120 (2024). DOI: 10.1016/j.fbio.2024.105120.
RECORD: Rec_0343400 VERIFIED: NO
Provenance & Taxonomy
Bos taurus [Animal]
99130
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antithrombotic
Thrombin
PaperSequence analysis and molecular docking of antithrombotic peptides from casein hydrolysate by trypsin digestion. Journal of Functional Foods 32:313-323 (2017). DOI: 10.1016/j.jff.2017.03.015.
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