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MYP_013048
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Basic Information
P6-2
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Antiretroviral
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
20 amino acids
C99H140N24O25S3
Standard
Sequence
LCDCPNGPWVWVPAFCQAVG
Physicochemical Analysis
2162.51 Da
4.05
-1.27
-1.52
-0.0634
0.62
0.26
0.40
22.56
73.00
0.1500
11000.00
11125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
744.91
-4.46
26.0
27.0
57.0
151.0
8.0
21.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0283537 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Antimicrobial Antiviral
PMID21543477 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21543477/
RECORD: Rec_0284841 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Fusion inhibition
HIV-1 (NL4-3)
2.3 μM
IC50
Mammalian: 5.5 h; Yeast: 3 min; E. coli: 2 min
PaperPeptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition. | Koedel Y, Eissmann K, Wend H, Fleckenstein B, Reil H. | J Virol. 2011 Jul;85(14):7037-47. | DOI:10.1128/JVI.02366-10 | PMID:21543477 PMID21543477 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21543477/
RECORD: Rec_0356164 VERIFIED: YES
Provenance & Taxonomy
GB virus C [Virus]
54290
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
TZM-bl
Qualitative inhibition
PaperPeptides derived from a distinct region of GB virus C glycoprotein E2 mediate strain-specific HIV-1 entry inhibition. PMID21543477 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21543477/
RECORD: Rec_0362813 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 35.0%, E 0.0%, T 40.0%, C 25.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperHIPdb: a database of experimentally validated HIV inhibiting peptides PMID23359817 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/23359817/
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