Peptide Database

Peptide NameSLAY-screened peptide P859

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length18 amino acids

Chemical FormulaC98H151N25O28

DescriptionStandard

        VTTFTNYYNRAVTLIHLT
    

Molecular Weight2127.40 Da

Isoelectric Point (pI)8.57

Net Charge (pH 7.0)0.82

Net Charge (pH 7.4) 0.55

Charge Density (pH 7.0) 0.0455

GRAVY Index0.24

Hydrophobic Moment 0.54

Boman Index0.18

Instability Index12.23

Aliphatic Index 102.78

Aromaticity 0.1667

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 876.39

LogP -7.87

H-bond Donors 32.0

H-bond Acceptors 30.0

Rotatable Bonds 64.0

Heavy Atoms 151.0

Ring Count 4.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0176693 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/