Peptide Database

Peptide NameI-8

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC88H146N22O16

DescriptionStandard

        VKRFKKFFLKLKSV
    

Molecular Weight1768.24 Da

Isoelectric Point (pI)11.39

Net Charge (pH 7.0)5.73

Net Charge (pH 7.4) 5.51

Charge Density (pH 7.0) 0.4092

GRAVY Index-0.03

Hydrophobic Moment 0.76

Boman Index-0.17

Instability Index1.59

Aliphatic Index 97.14

Aromaticity 0.2143

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 653.85

LogP -1.27

H-bond Donors 24.0

H-bond Acceptors 22.0

Rotatable Bonds 64.0

Heavy Atoms 126.0

Ring Count 3.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0325075 VERIFIED: YES

Provenance & Taxonomy

Organismcationic host defense peptides [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetMCF-7/Taxol

Activity65.2±4.2 μM

MethodIC50

PaperPro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane. Amino Acids. 2017 Sep;49(9):1601-1610. doi: 10.1007/s00726-017-2453-y. PMID: 28664269. PMID28664269 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28664269/

RECORD: Rec_0345661 VERIFIED: YES