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MYP_012847
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Basic Information
Cliotide T15
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Defense peptide
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
29 amino acids
C135H217N37O40S6
Standard
Sequence
GLPICGETCFKTKCYTKGCSCSYPVCKRN
Physicochemical Analysis
3190.78 Da
8.89
3.70
3.40
0.1275
-0.26
0.32
-0.07
40.29
36.90
0.1034
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1248.52
-15.01
50.0
50.0
102.0
218.0
5.0
29.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0060076 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
N-terminal acetylation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
2.5 μM
MIC
PaperImmunostimulating and Gram-negative-specific antibacterial cyclotides from the butterfly pea (Clitoria ternatea) | Nguyen et al., 2016 | Serra et al., 2016 | Gilding et al., 2016 PMID27007913 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27007913/
RECORD: Rec_0161964 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
N-terminal acetylation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
0.5 μM
MIC
PaperImmunostimulating and Gram-negative-specific antibacterial cyclotides from the butterfly pea (Clitoria ternatea) | Nguyen et al., 2016 | Serra et al., 2016 | Gilding et al., 2016 PMID27007913 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27007913/
RECORD: Rec_0168606 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
N-terminal acetylation
Bio-Activity Profile
Antimicrobial Antibacterial
Caenorhabditis elegans
PaperImmunostimulating and Gram-negative-specific antibacterial cyclotides from the butterfly pea (Clitoria ternatea) | Nguyen et al., 2016 | Serra et al., 2016 | Gilding et al., 2016 PMID27007913 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27007913/
RECORD: Rec_0173660 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
43366
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Escherichia coli
0.5 μM
MIC
PaperImmunostimulating and Gram-negative-specific Antibacterial Cyclotides from the Butterfly Pea Clitoria ternatea
RECORD: Rec_0231231 VERIFIED: YES
Provenance & Taxonomy
Clitoria ternatea [Plant]
Cyclotide
43366
Structure & Mods
head-to-tail cyclic peptide scaffold [Cyclic]
canonical L-amino-acid peptide [L]
Acetylation
Cysteine-rich scaffold consistent with multiple disulfide bonds in the annotated family
N-terminal acetylation
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
PaperImmunostimulating and Gram-negative-specific antibacterial cyclotides from the butterfly pea (Clitoria ternatea) | Nguyen et al., 2016 | Serra et al., 2016 | Gilding et al., 2016 PMID27007913 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27007913/
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