Peptide Database

Peptide NameSLAY-screened peptide P2471

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC107H151N29O31

DescriptionStandard

        GLLSPWSVRFNYHDPDADHL
    

Molecular Weight2339.52 Da

Isoelectric Point (pI)5.13

Net Charge (pH 7.0)-2.06

Net Charge (pH 7.4) -2.37

Charge Density (pH 7.0) -0.1032

GRAVY Index-0.60

Hydrophobic Moment 0.26

Boman Index0.03

Instability Index28.18

Aliphatic Index 78.00

Aromaticity 0.1500

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 6990.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 949.37

LogP -7.54

H-bond Donors 32.0

H-bond Acceptors 31.0

Rotatable Bonds 68.0

Heavy Atoms 167.0

Ring Count 8.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0272745 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/