Peptide Database

Peptide NameIns1C:37-61 (insulin-1 C-peptide fragment)

Function Ontology

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC114H190N32O40

DescriptionStandard

        PQVEQLELGGSPGDLQTLALEVARQ
    

Molecular Weight2648.92 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-3.03

Net Charge (pH 7.4) -3.09

Charge Density (pH 7.0) -0.1213

GRAVY Index-0.30

Hydrophobic Moment 0.52

Boman Index0.04

Instability Index65.25

Aliphatic Index 109.20

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1162.86

LogP -12.79

H-bond Donors 38.0

H-bond Acceptors 37.0

Rotatable Bonds 89.0

Heavy Atoms 186.0

Ring Count 2.0

Amide Bonds 28.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0084686 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyInsulin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

MHC class II-presented autoantigen T-cell epitope Type 1 diabetes-associated

TargetI-A^g7 MHC class II; autoreactive CD4+ T cells

MethodMHC-II peptidomics / competitive MHC-II binding / CD4+ T-cell assay