Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length462 amino acids

Chemical FormulaC2325H3674N604O651S14

DescriptionStandard

        MASGPGSVRRWATLVVLVALGTAVTTTTNPGIVARVTQKGLDYACQQGVLTLQKELEKITIPTFSGNFKIKYLGKGQYSFFSMVIQGFNLPNSQIRPLPDEGLDLSIRDASIKIRGKWKARKNFIKLGGNFDLSVEGISISAGLSLGYDPDSGHSTVTCPRCSSHINTVRIRISGSSVGWLIQLFHKRIESSLQNSMTSKICEVVTSTVSSKLQPYFQTLPVTTKLDKVAGVDYSLVAPPRVTADNLDGLLKGEFFSLAHRSPPPFAPPALAFPTDHDRMVYLGISEYFFNTAGFVYQKARALNLTLRDDMIPKESMFRLTTKFFGTLIPQVAKMFPDMQMQLFIWASLPPKLTVNPNGLNLIFVLDTQAFAILPNSSLDPLFLLEMNLNLSVVVGARSDRLIGELRLDKGGTFTLTSALISNAEKLQRGFPLPLPAYIKLFNLILQPYQDFLLFGADVHYS
    

Molecular Weight50952.61 Da

Isoelectric Point (pI)9.44

Net Charge (pH 7.0)12.01

Net Charge (pH 7.4) 11.34

Charge Density (pH 7.0) 0.0260

GRAVY Index0.10

Hydrophobic Moment 0.64

Boman Index0.13

Instability Index29.14

Aliphatic Index 99.18

Aromaticity 0.0974

Extinction Coeff. Reduced 39880.00

Extinction Coeff. Oxidized 40130.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0126999 VERIFIED: NO

Provenance & Taxonomy

OrganismCapra hircus [Animal]

FamilyBPI/LBP

Tax ID9925

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-negative Cytotoxic Non-hemolytic

TargetGram-negative bacteria