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MYP_012696
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Basic Information
Gallinacin 12
Anticancer
Antimicrobial
Venom / Toxin ▸ General toxin ▸ Toxicity
Standard
41 amino acids
C177H285N55O53S6
Standard
Sequence
DTVACRIQGNFCRAGACPPTFTISGQCHGGLLNCCAKIPAQ
Physicochemical Analysis
4223.88 Da
8.35
1.79
1.44
0.0436
0.20
0.62
0.12
39.94
66.83
0.0488
0.00
375.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1713.12
-22.71
63.0
62.0
132.0
291.0
6.0
45.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0227867 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Toxicity
Streptococcus pyogenes
27 μM
LD50
PaperModification of chicken avian beta-defensin-8 at positively selected amino acid sites enhances specific antimicrobial activity
RECORD: Rec_0252548 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Toxicity
Staphylococcus aureus
>27 μM
LD50
PaperModification of chicken avian beta-defensin-8 at positively selected amino acid sites enhances specific antimicrobial activity
RECORD: Rec_0337577 VERIFIED: NO
Provenance & Taxonomy
Gallus gallus [Animal]
Defensin
9031
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
5-27; 12-34; 17-35
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0341895 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0347287 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Toxicity
S-typhimurium
>27 μM
LD50
PaperModification of chicken avian beta-defensin-8 at positively selected amino acid sites enhances specific antimicrobial activity
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