Peptide Database

Peptide NameSLAY-screened peptide P4774

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC78H126N26O21S

DescriptionStandard

        HPQTCFRTPSAKPIRG
    

Molecular Weight1796.06 Da

Isoelectric Point (pI)10.86

Net Charge (pH 7.0)2.84

Net Charge (pH 7.4) 2.57

Charge Density (pH 7.0) 0.1773

GRAVY Index-0.96

Hydrophobic Moment 0.44

Boman Index-0.24

Instability Index21.63

Aliphatic Index 30.62

Aromaticity 0.0625

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 755.73

LogP -9.30

H-bond Donors 27.0

H-bond Acceptors 26.0

Rotatable Bonds 53.0

Heavy Atoms 126.0

Ring Count 5.0

Amide Bonds 16.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0111290 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/