MYP_012660
Beta-insect depressant toxin BmKIT2 (Depressant insect toxin BmK IT2)
Antimicrobial
Standard
61 amino acids
C287H430N80O87S8
Standard
DGYIKGKSGCRVACLIGNQGCLKDCRAYGASYGYCWTWGLACWCEGLPDNKTWKSESNTCG
6649.49 Da
8.18
1.68
1.34
0.0276
-0.40
0.55
0.02
24.80
49.67
0.1311
27960.00
28460.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Amino Acid Composition
2698.98
-30.23
104.0
97.0
213.0
462.0
13.0
64.0
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0016218
VERIFIED: YES
Provenance & Taxonomy
Mesobuthus martensii [Animal]
Defensin
34649
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Neurotoxic
Sodium-channel modulator
Antimicrobial
Rat dorsal root ganglion voltage-gated sodium channels
Whole-cell patch-clamp electrophysiology
RECORD: Rec_0431992
VERIFIED: YES
Provenance & Taxonomy
Mesobuthus martensii [Animal]
Structure & Mods
Bio-Activity Profile
Neurotoxic
Sodium-channel binding
Insect neuronal membrane sodium-channel binding site (high-affinity)
0.65±0.20 nM
Kd (125I-BmK IT2 radioligand binding assay)
RECORD: Rec_0431993
VERIFIED: YES
Provenance & Taxonomy
Mesobuthus martensii [Animal]
Structure & Mods
Bio-Activity Profile
Neurotoxic
Sodium-channel binding
Insect neuronal membrane sodium-channel binding site (low-affinity)
78.7±16.4 nM
Kd (125I-BmK IT2 radioligand binding assay)