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MYP_012631
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Basic Information
Antimicrobial peptide, Pleurocidin-like peptide YT2
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
25 amino acids
C136H209N39O29
Standard
Sequence
RWGKWFKKATHVGKHVGKAALTAYL
Physicochemical Analysis
2854.36 Da
10.68
5.93
5.62
0.2371
-0.40
0.70
0.01
5.37
70.40
0.1600
12490.00
12490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1103.35
-6.35
41.0
37.0
93.0
204.0
8.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0002363 VERIFIED: NO
Provenance & Taxonomy
Pleuronectes ferrugineus,Limanda ferruginea [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial
RECORD: Rec_0013044 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Biotinylation
Amidation
Bio-Activity Profile
Antimicrobial
4T1
5 μM
Concentration response
PaperPleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts PMID22023734 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22023734/
RECORD: Rec_0016486 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Pleurocidin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Biotinylation
Amidation
Bio-Activity Profile
Antimicrobial
MDA-MB-468
50 μM
Concentration response
PaperPleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts PMID22023734 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22023734/
RECORD: Rec_0024979 VERIFIED: YES
Provenance & Taxonomy
Yellowtail flounder [Animal]
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
C-terminal NH2
Bio-Activity Profile
Antimicrobial Antifungal Anticancer
Pseudomonas aeruginosa Z61
2 μM
MIC
PaperNovel antimicrobial peptides derived from flatfish genes PMID12878506 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12878506/
RECORD: Rec_0030869 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
Evidence URLhttps://patents.google.com/patent/US20060093596A1/en PatentUS 2006/0093596 A1
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