Peptide Database

Peptide NamePlecanatide

Function Ontology

Guanylate cyclase-C agonist Gastrointestinal secretagogue

Standard StatusStandard

Sequence Length16 amino acids

Chemical FormulaC65H108N18O26S4

DescriptionStandard

        NDECELCVNVACTGCL
    

Molecular Weight1685.92 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-3.27

Net Charge (pH 7.4) -3.54

Charge Density (pH 7.0) -0.2046

GRAVY Index0.57

Hydrophobic Moment 0.27

Boman Index0.16

Instability Index86.69

Aliphatic Index 91.25

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 250.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 718.13

LogP -9.22

H-bond Donors 27.0

H-bond Acceptors 27.0

Rotatable Bonds 54.0

Heavy Atoms 113.0

Ring Count 0.0

Amide Bonds 17.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0074186 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]; synthetic construct [Synthetic]

FamilyGuanylin analogue

Tax ID9606;32630

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide4-12, 7-15

Bio-Activity Profile

Function

Guanylate cyclase-C agonist Gastrointestinal secretagogue

TargetGuanylate cyclase-C on intestinal epithelium

Half-LifeClinical/Human: Half-life (t?) cannot be calculated due to negligible systemic absorbance