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MYP_012598
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Basic Information
Unnamed
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Enzyme modulation ▸ Enzyme inhibition ▸ Phosphodiesterase inhibition ▸ CaMPDE inhibitor
Other / Curated residual function label ▸ Generic enzyme inhibition annotation
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
25 amino acids
C149H232N38O33S
Standard
Sequence
VYQHQKAMKPWIQPKTKVIPYVRYL
Physicochemical Analysis
3115.74 Da
10.12
4.81
4.54
0.1926
-0.60
0.46
-0.05
2.56
85.60
0.1600
9970.00
9970.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1155.99
-4.08
39.0
40.0
98.0
221.0
9.0
27.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0207728 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Enzyme inhibitory
Calmodulin-dependent cyclic nucleotide phosphodiesterase
1.1 μM
IC50
RECORD: Rec_0225299 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Lactoferricin
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Escherichia coli; Staphylococcus carnosus
Bacterial kill assay (log(N0/Nf))
PaperIdentification of the initial binding sites of αs2-casein f(183-207) and effect on bacterial membranes and cell morphology | Lopez-Exposito, I. et al. | DOI: 10.1016/j.bbamem.2008.06.018 Evidence URLhttps://www.uniprot.org/uniprotkb/P02663/entry
RECORD: Rec_0254953 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
Casein-derived peptide
9913
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
332 μM
MIC
RECORD: Rec_0270568 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
alpha-S2-Casein-derived
9913
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative
Listeria monocytogenes; Cronobacter sakazakii
MIC
PaperStructure-activity relationship of synthetic variants of the milk-derived antimicrobial peptide αs2-casein f(183-207) | Alvarez-Ordonez, A. et al. | DOI: 10.1128/AEM.01394-13 Evidence URLhttps://www.uniprot.org/uniprotkb/P02663/entry
RECORD: Rec_0333545 VERIFIED: YES
Provenance & Taxonomy
Bos taurus [Animal]
9913
Structure & Mods
proteolytic peptide fragment [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
PaperImproved functionality of fermented milk is mediated by the synbiotic interaction between Cudrania tricuspidata leaf extract and Lactobacillus gasseri strains; Identification of two distinct antibacterial domains within the sequence of bovine alpha(s2)-casein PMID26996626;10434050 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26996626/
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