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MYP_012594
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Basic Information
Brevinin-1ISa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
24 amino acids
C114H196N32O28S2
Standard
Sequence
FLPGVLRLVTKVGPAVVCAITRNC
Physicochemical Analysis
2527.10 Da
9.70
2.74
2.51
0.1141
1.10
0.68
0.28
26.99
133.75
0.0417
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
948.41
-7.28
35.0
33.0
78.0
176.0
3.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0009466 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Brevinin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
18-24
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
3.1 μM
MIC
PaperE. Iwakoshi-Ukena et al. / BBRC 412 (2011) 673-677. Characterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning Evidence URLhttps://www.uniprot.org/uniprotkb/G3XHP2/entry
RECORD: Rec_0052817 VERIFIED: NO
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial
RECORD: Rec_0105572 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0157955 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
50 μM
MIC
PaperCharacterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning
RECORD: Rec_0175605 VERIFIED: YES
Provenance & Taxonomy
Odorrana ishikawae [Animal]
Brevinin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
18-24
Bio-Activity Profile
Antimicrobial Antifungal
MIC>100 uM, Staphylococcus aureus or MRSA
3.1 μM
MIC
PaperCharacterization of novel antimicrobial peptides from the skin of the endangered frog Odorrana ishikawae by shotgun cDNA cloning
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