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MYP_012531
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Basic Information
Pcr-Δ7
Antimicrobial
Antiviral
Antiviral ▸ Anti-Retrovirus ▸ Anti-HTLV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
23 amino acids
C117H191N35O35S
Standard
Sequence
CFLNITNSHVSILQERPPLENRV
Physicochemical Analysis
2680.05 Da
6.75
-0.16
-0.43
-0.0068
-0.20
0.38
-0.03
69.80
110.00
0.0435
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1146.07
-11.73
39.0
37.0
86.0
188.0
4.0
26.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0062974 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HTLV Fusion inhibition
HTLV | T cell; 293T cells
0.19±0.01 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperBasic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry. | Lamb D, Mirsaliotis A, Kelly SM, Brighty DW. | J Biol Chem. 2009 Mar 6;284(10):6575-84. | DOI:10.1074/jbc.M806725200 | PMID:19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0099882 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0141756 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 13.0%, E 0.0%, T 39.1%, C 47.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0171150 VERIFIED: YES
Provenance & Taxonomy
Human T-lymphotropic virus 1 [Virus]
Virus-derived peptide
11908;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Human T-cell leukaemia virus 1 (Virus entry); 293T
0.19 μM
Luciferase assay
PaperBasic residues are critical to the activity of peptide inhibitors of human T cell leukemia virus type 1 entry. | Lamb D, Mirsaliotis A, Kelly SM, Brighty DW. | J Biol Chem. 2009 | PMID:19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/
RECORD: Rec_0231858 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Human T cell leukemia virus type 1(HTLV-1):inhibition of mambrane fusion in 293T cells
0.19±0.01 μM
IC50
PaperPubMed PMID: 19114713 PMID19114713 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19114713/