Peptide Database

Peptide NameSLAY-screened peptide P139

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC116H172N32O24S

DescriptionStandard

        RWALEPHSIWFHLKKMHLT
    

Molecular Weight2430.87 Da

Isoelectric Point (pI)9.99

Net Charge (pH 7.0)2.02

Net Charge (pH 7.4) 1.66

Charge Density (pH 7.0) 0.1064

GRAVY Index-0.42

Hydrophobic Moment 0.37

Boman Index0.06

Instability Index84.68

Aliphatic Index 87.37

Aromaticity 0.1579

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11000.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 887.65

LogP -2.06

H-bond Donors 32.0

H-bond Acceptors 30.0

Rotatable Bonds 76.0

Heavy Atoms 173.0

Ring Count 9.0

Amide Bonds 18.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0329716 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/