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MYP_012438
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Basic Information
Caerin 1.20
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
25 amino acids
C124H200N32O29
Standard
Sequence
GLFGILGSVAKHVLPHVIPVVAEHL
Physicochemical Analysis
2603.11 Da
7.02
0.02
-0.33
0.0009
1.18
0.42
0.52
25.15
159.60
0.0400
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
913.73
-3.34
30.0
32.0
80.0
185.0
6.0
24.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0206002 VERIFIED: YES
Provenance & Taxonomy
Pelodryas caerulea [Animal],Ranoidea splendida [Animal]
Caerin
30344,30345
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antiviral Anti-HIV Release inhibition
Human immunodeficiency virus (HIV) | T cells
7 μM
IC50
Mammalian: 30 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of HIV infection by caerin 1 antimicrobial peptides. | VanCompernolle S, Smith PB, Bowie JH, Tyler MJ, Unutmaz D, Rollins-Smith LA. | Peptides. 2015 Sep;71:296-303. | DOI:10.1016/j.peptides.2015.05.004 | PMID:26026377 PMID26026377 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0264926 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]; Litoria caerulea [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
P.multocida
>100 μg/mL
MIC
PaperHost-defence peptide profiles of the skin secretions of interspecific hybrid tree frogs and their parents, female Litoria splendida and male Litoria caerulea.
RECORD: Rec_0288351 VERIFIED: YES
Provenance & Taxonomy
Litoria caerulea [Animal],Litoria splendida [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral Cytotoxic
Human endocervical cells End1/E6E7
PMID26026377;33008028 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0310718 VERIFIED: YES
Provenance & Taxonomy
Litoria caerulea [Animal],Litoria splendida [Animal]
Caerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Human immunodeficiency virus (HIV):inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells
7 μM
IC50
PMID26026377;33008028 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26026377/
RECORD: Rec_0324759 VERIFIED: YES
Provenance & Taxonomy
Litoria splendida [Animal]; Litoria caerulea [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antiviral
L. innocua
25 μg/mL
MIC
PaperHost-defence peptide profiles of the skin secretions of interspecific hybrid tree frogs and their parents, female Litoria splendida and male Litoria caerulea.
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