Peptide Database

Peptide NameLariatin (Class II lasso peptide) (Lariat peptide) (Ribosomally synthesized and post-translationally modified peptide) (RiPP) [Cleaved into: Lariatin-A; Lariatin-B]

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length46 amino acids

Chemical FormulaC225H359N67O65S

DescriptionStandard

        MTSQPSKKTYNAPSLVQRGKFARTTAGSQLVYREWVGHSNVIKPGP
    

Molecular Weight5074.73 Da

Isoelectric Point (pI)10.64

Net Charge (pH 7.0)5.58

Net Charge (pH 7.4) 5.31

Charge Density (pH 7.0) 0.1214

GRAVY Index-0.71

Hydrophobic Moment 0.45

Boman Index-0.10

Instability Index14.83

Aliphatic Index 57.17

Aromaticity 0.0870

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2147.19

LogP -25.63

H-bond Donors 75.0

H-bond Acceptors 73.0

Rotatable Bonds 163.0

Heavy Atoms 358.0

Ring Count 10.0

Amide Bonds 50.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0011022 VERIFIED: YES

Provenance & Taxonomy

OrganismRhodococcus jostii [other]

Structure & Mods

Configlasso-peptide topology [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Bacteriocin Anti-tuberculosis Anti-Gram-positive Non-hemolytic

TargetM. smegmatis (Gram-positive)

RECORD: Rec_0021553 VERIFIED: NO

Provenance & Taxonomy

OrganismRhodococcus jostii [other]

FamilyBacteriocin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial

RECORD: Rec_0075710 VERIFIED: YES

Provenance & Taxonomy

OrganismRhodococcus jostii [other]

Structure & Mods

Configlasso-peptide topology [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Bacteriocin Anti-tuberculosis Anti-Gram-positive Non-hemolytic

TargetMycobacterium species (Gram-positive)

RECORD: Rec_0331224 VERIFIED: YES

Provenance & Taxonomy

OrganismRhodococcus jostii [other]

Structure & Mods

Configlasso-peptide topology [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Bacteriocin Anti-tuberculosis Anti-Gram-positive Non-hemolytic

TargetM. tuberculosis (Gram-positive)