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MYP_012423
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Basic Information
Pepthiomycin A
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Mycobacterium
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
12 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
NXTAVAILAXLE
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0311359 VERIFIED: YES
Provenance & Taxonomy
Natural source unresolved [other]
Natural peptide
Structure & Mods
topology not specified [Not included yet]
noncanonical stereochemical modification [Modified]
Non-standard residues/chemistry in sequence: NOTAVAILABLE
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial Antifungal
Mycobacterium 607
MIC
PMID950316 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/950316/
RECORD: Rec_0329564 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. [Bacterium]
Nonribosomal peptide
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Non-standard residues/chemistry in sequence: NOTAVAILABLE
Bio-Activity Profile
Antimicrobial Antimycobacterial Antifungal
Mycobacterium tuberculosis H37Rv
50 μg/mL
MIC
PMID855995 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/855995/
RECORD: Rec_0336592 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. [Bacterium]
Natural peptide
Structure & Mods
topology not specified [Not included yet]
noncanonical stereochemical modification [Modified]
Non-standard residues/chemistry in sequence: NOTAVAILABLE
Bio-Activity Profile
Antimicrobial Antimycobacterial
Mycobacterium smegmatis ATCC 607
MIC
PMID28292 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/28292/
RECORD: Rec_0337544 VERIFIED: YES
Provenance & Taxonomy
Bacillus sp. [Bacterium]
Natural peptide
Structure & Mods
topology not specified [Not included yet]
noncanonical stereochemical modification [Modified]
Non-standard residues/chemistry in sequence: NOTAVAILABLE
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis H37Rv
MIC
PMID1112764 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1112764/
RECORD: Rec_0348416 VERIFIED: YES
Provenance & Taxonomy
Streptomyces sp. [Bacterium]
Natural peptide
Structure & Mods
branched peptide architecture [Branched]
all-D amino-acid peptide [D]
Non-standard residues/chemistry in sequence: NOTAVAILABLE
Bio-Activity Profile
Antimicrobial Antimycobacterial Antibacterial
Mycobacterium tuberculosis H37Rv
IC50
PMID25681127 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25681127/
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