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MYP_012385
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Basic Information
Gaegurin-5 (1-13)[F6W;,K7,11H;V8A;A9L;V12L], LL-1c
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C73H108N18O15
Standard
Sequence
FLGALWHALSHLL
Physicochemical Analysis
1477.75 Da
6.92
-0.07
-0.37
-0.0050
1.30
0.36
0.62
39.13
165.38
0.1538
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
505.90
0.01
18.0
17.0
44.0
106.0
5.0
12.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0181747 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer Hemolytic
Human erythrocytes: 0% Hemolysis=30 μM
PMID22526264 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526264/
RECORD: Rec_0225652 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Gaegurin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic
Human lung carcinoma A549
59 μM
IC50
PMID22526264 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526264/
RECORD: Rec_0359402 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Gaegurin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Staphylococcus aureus ATCC 25923
8 μM
MIC
PMID22526264 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526264/
RECORD: Rec_0368938 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Anticancer
PANC-1
>120 μM
IC50
PMID22526264 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526264/
RECORD: Rec_0388364 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Gaegurin
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer Cytotoxic
Human pancreatic carcinoma Panc-1
120 μM
IC50
PMID22526264 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22526264/
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