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MYP_012338
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Basic Information
HR2-30a
Antimicrobial
Antiviral
Antiviral ▸ Anti-Pneumovirus ▸ Anti-RSV
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition ▸ Fusion inhibitor
Standard
45 amino acids
C223H346N60O74
Standard
Sequence
NFYDPLVFPSDEFDASISQVNEKINQSLASIRKSDELLHNVNAGK
Physicochemical Analysis
5051.49 Da
4.65
-3.14
-3.41
-0.0699
-0.51
0.65
-0.04
42.43
86.67
0.0889
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
2199.12
-24.63
72.0
72.0
169.0
357.0
7.0
51.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0064183 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
respiratory syncytial virus(RSV):inhibition of cell fusion in Hep2 cells
2.93 μM
IC50
PaperPubMed PMID: 12615056 PMID12615056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12615056/
RECORD: Rec_0166327 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-RSV Fusion inhibition
Respiratory syncytial virus(RSV) | of cell; Hep2 cells
2.93 μM
IC50
Mammalian: 1.4 h; Yeast: 3 min; E. coli: >10 h
PaperBoth heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion. | Wang E, Sun X, Qian Y, Zhao L, Tien P, Gao GF. | Biochem Biophys Res Commun. 2003 Mar 14;302(3):469-75. | DOI:10.1016/s0006-291x(03)00197-9 | PMID:12615056 PMID12615056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12615056/
RECORD: Rec_0233244 VERIFIED: YES
Provenance & Taxonomy
Human orthopneumovirus [Virus]
Heptad repeat peptide
11250;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Fusion inhibitor
Respiratory syncytial virus (Fusion); Hep2
2.93 μM
Cell-fusion assay
PaperBoth heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion. | Wang E, Sun X, Qian Y, Zhao L, Tien P, Gao GF. | Biochem Biophys Res Commun. 2003 | PMID:12615056 PMID12615056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12615056/
RECORD: Rec_0370401 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 12615056 PMID12615056 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12615056/
RECORD: Rec_0390631 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 68.9%, E 0.0%, T 11.1%, C 20.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/