Peptide Database

Peptide Name4286(derived from DNA-polymerase domain of HIV-1 RT (20-mers))

Function Ontology

Antimicrobial

Antiviral

Antiviral ▸ Anti-HIV ▸ Anti-HIV-1

Antiviral ▸ Antiviral mechanism ▸ Viral replication inhibition

Enzyme modulation ▸ Enzyme inhibition ▸ Integrase inhibition

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC116H180N28O32S

DescriptionStandard

        KILEPFRKQNPDIVIYQYMD
    

Molecular Weight2510.90 Da

Isoelectric Point (pI)6.22

Net Charge (pH 7.0)-0.24

Net Charge (pH 7.4) -0.45

Charge Density (pH 7.0) -0.0118

GRAVY Index-0.65

Hydrophobic Moment 0.49

Boman Index-0.08

Instability Index54.71

Aliphatic Index 92.50

Aromaticity 0.1500

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 994.21

LogP -4.90

H-bond Donors 32.0

H-bond Acceptors 33.0

Rotatable Bonds 82.0

Heavy Atoms 177.0

Ring Count 5.0

Amide Bonds 22.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0334686 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyProtein-derived synthetic peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antiviral Anti-HIV-1 Replication inhibition

TargetHIV-1

Activity4.8 μM

MethodIC50

Half-LifeMammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min

PaperPeptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase. | Oz Gleenberg I, Avidan O, Goldgur Y, Herschhorn A, Hizi A. | J Biol Chem. 2005 Jun 10;280(23):21987-96. | DOI:10.1074/jbc.M414679200 | PMID:15790559 PMID15790559 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15790559/

RECORD: Rec_0382054 VERIFIED: YES