Peptide Database

Peptide NameNoD173(Q22K)

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length47 amino acids

Chemical FormulaC223H381N75O62S8

DescriptionStandard

        RQCKAESNTFTGICIAKPPCRKACIREKFTDGHCSKVLRRCLCTKRC
    

Molecular Weight5361.40 Da

Isoelectric Point (pI)9.58

Net Charge (pH 7.0)8.77

Net Charge (pH 7.4) 8.39

Charge Density (pH 7.0) 0.1866

GRAVY Index-0.49

Hydrophobic Moment 0.62

Boman Index-0.30

Instability Index56.27

Aliphatic Index 54.04

Aromaticity 0.0426

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2260.00

LogP -26.98

H-bond Donors 90.0

H-bond Acceptors 80.0

Rotatable Bonds 183.0

Heavy Atoms 368.0

Ring Count 5.0

Amide Bonds 48.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0018152 VERIFIED: YES

Provenance & Taxonomy

OrganismNicotiana occidentalis [Plant]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetHeLa

Activity0.7±0.07 μM

MethodIC50

RECORD: Rec_0155206 VERIFIED: YES

Provenance & Taxonomy

OrganismNicotiana occidentalis [Plant]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Cytotoxic

RECORD: Rec_0369232 VERIFIED: YES

Provenance & Taxonomy

OrganismNicotiana occidentalis [Plant]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetPC-3

Activity2.86±0.14 μM

MethodIC50

RECORD: Rec_0373059 VERIFIED: YES

Provenance & Taxonomy

OrganismNicotiana occidentalis [Plant]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer

TargetMM170

Activity0.87±0.04 μM

MethodIC50

RECORD: Rec_0380149 VERIFIED: YES

Provenance & Taxonomy

OrganismNicotiana occidentalis [Plant]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermNone

Bio-Activity Profile

Function

Antimicrobial Anticancer Hemolytic

TargetHuman red blood cells: with ∼12% lysis at the very high concentration (100 μM)